Journal article
Renal proximal tubule angiotensin AT1A receptors regulate blood pressure
H Li, ET Weatherford, DR Davis, HL Keen, JL Grobe, A Daugherty, LA Cassis, AM Allen, CD Sigmund
American Journal of Physiology Regulatory Integrative and Comparative Physiology | Published : 2011
Abstract
All components of the renin angiotensin system necessary for ANG II generation and action have been reported to be present in renal proximal convoluted tubules. Given the close relationship between renal sodium handling and blood pressure regulation, we hypothesized that modulating the action of ANG II specifically in the renal proximal tubules would alter the chronic level of blood pressure. To test this, we used a proximal tubule-specific, androgen-dependent, promoter construct (KAP2) to generate mice with either overexpression of a constitutively active angiotensin type 1A receptor transgene or depletion of endogenous angiotensin type 1A receptors. Androgen administration to female transg..
View full abstractGrants
Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
Transgenic mice were generated at the University of Iowa Transgenic Animal Facility supported in part by grants from the National Institutes of Health and from the Roy J. and Lucille A. Carver College of Medicine. This work was also supported through research grants from the National Heart, Lung, and Blood Institute to C. D. Sigmund (HL-084207, HL-048058, and HL-061446), L. A. Cassis (HL-073085), and A. Daugherty (HL-062846 and HL-080100), and the Australian National Health and Medical Research Council to A. M. Allen (566563). J. L. Grobe was supported by a K99/R00 "Pathway to Independence" award from the National Heart, Lung, and Blood Institute (HL-098276). H. Li was supported through a Postdoctoral Fellowship from the American Heart Association. The authors also gratefully acknowledge the generous research support of the Roy J. Carver Trust.